Phylogenetic diversity of Escherichia coli strains producing NDM-type carbapenemases

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Phylogenetic diversity of Escherichia coli strains producing NDM-type carbapenemases.

BACKGROUND The global accumulation of Escherichia coli with CTX-M extended-spectrum β-lactamases partly reflects the dissemination of clonal lineages, notably ST131 and ST405. More recently, E. coli have emerged that produce NDM carbapenemase. We sought to determine the clonal diversity of E. coli with this enzyme from English hospitals, and to compare them with isolates from Pakistan and India...

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Escherichia coli (E. coli) is a normal inhabitant of the gastrointestinal tract of vertebrates, including humans. Phylogenetic analysis has shown that E. coli is composed of four main phylogenetic groups (A, B1, B2 and D). Group A and B1 are generally associated with commensals, whereas group B2 is associated with extra-intestinal pathotypes. Most enteropathogenic isolates, however, are assigne...

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Correspondence and reprint requests should be addressed to: Prof. Alejandro Cravioto, Deputy Executive Director ICDDR,B: Centre for Health and Population Research GPO Box 128, Dhaka 1000 (Mohakhali, Dhaka 1212) Bangladesh Email: [email protected] The production of a heat-labile protein unrelated to cholera toxin was described in the 1960s in studies of Escherichia coli isolated from animals ...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2011

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dkr226